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Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang
《医学前沿（英文）》 2020年 第14卷 第5期 页码 642-650 doi: 10.1007/s11684-019-0719-3
关键词： type 2 diabetes mellitus diabetic kidney disease miR-154-5p urinary albumin to creatinine ratio
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《医学前沿（英文）》 2017年 第11卷 第1期 页码 110-119 doi: 10.1007/s11684-016-0484-5
This study aims to investigate the link between glycated hemoglobin and diabetic complications with chronic periodontitis. A total of 207 patients with type 2 diabetes and chronic periodontitis (CP) were divided according to tertiles of mean PISA (periodontal inflamed surface area) scores as low, middle and high PISA groups. Simultaneously a group of 67 periodontally healthy individuals (PH) was recruited. Periodontal examinations, including full-mouth assessment of probing depths (PPD), bleeding on probing, clinical attachment level and plaque scores were determined. Blood analyses were carried out for glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), 2 h post parandial glucose (PPG). Individuals in PH group had significantly better glycemic control than CP group. Upon one-way analysis of variance, subjects with increased PISA had significantly higher HbA1c levels, retinopathy and nephropathy (P<0.05). After controlling for age, gender, body mass index (BMI), socioeconomic status (SES), family history of diabetes and periodontitis, duration of diabetes, the mean PISA in mm2, PPD 4--6 mm (%) and PPD≥7 mm (%) emerged as significant predictors for elevated HbA1c in regression model (P<0.05). Logistic regression analysis revealed that PISA was associated with higher risk of having retinopathy and neuropathy (odds ratio). In our study, the association between glycemic control and diabetic complications with periodontitis was observed.
关键词： type 2 diabetes mellitus hemoglobin A glycated chronic periodontitis
Cytokines and inflammation in adipogenesis: an updated review
Ning Jiang, Yao Li, Ting Shu, Jing Wang
《医学前沿（英文）》 2019年 第13卷 第3期 页码 314-329 doi: 10.1007/s11684-018-0625-0
关键词： cytokines inflammation adipogenesis type 2 diabetes mellitus metabolic disorder
肝脏移植术后糖尿病患者肠道微生物组的变化 Article
凌琪, 韩玉秋, 马越, 王晓森, 朱铮, 王靖宇, 曹佳莹, 林笑含, 王军, 王保红
《工程（英文）》 2023年 第31卷 第12期 页码 98-111 doi: 10.1016/j.eng.2023.09.006
移植后糖尿病（PTDM）会增加肝移植（LT）受者移植失败和死亡的风险。实验研究表明免疫抑制性他克莫司（TAC）介导的肠道生态失调可能导致血糖紊乱，但仍尚未见相关临床研究报道。 因此，本研究通过高通量鸟枪法宏基因组测序和代谢组学分析相结合的方法，对PTDM和非PTDM的肝脏移植受者队列中的肠道微生物组（IM）进行了表征，并破译了IM、TAC剂量和PTDM之间的潜在关联。 通过与非 PTDM 和经典II型糖尿病（T2DM）进行对比分析，确定了PTDM患者的肠道微生物组代表性特征为：变形菌门富集和拟杆菌门减少。有趣的是，与改变的微生物代谢产物相一致，这些微生物在PTDM患者中的丰都变化与TAC的剂量显著关联。 具体来说，与低TAC 谷浓度（< 5 ng∙mL–1） 的移植受体相比较，高 TAC 谷浓度（> 5 ng∙mL–1）移植受者中的有益微生物水平被显著降低；同时，通过检测粪便代谢物发现其中参与α-亚麻酸和花生四烯酸-这些降低糖尿病发生的有益代谢物的显著降低。更进一步，这些微生物标签分子的变化与移植受者的血糖紊乱程度显著有关。 总之，PTDM患者的粪便微生物组和代谢组发生了显著变化，且与 TAC 剂量相关。 这项研究是首个探索PTDM患者的细菌分类学组成变化和细菌基因功能变化，以更好地理解IM对PTDM的影响。
Impact of diabetes and its treatments on skeletal diseases
null
《医学前沿（英文）》 2013年 第7卷 第1期 页码 81-90 doi: 10.1007/s11684-013-0243-9
Diabetes mellitus is an enormous menace to public health globally. This chronic disease of metabolism will adversely affect the skeleton if not controlled. Both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are associated with an increased risk of osteoporosis and fragility fractures. Bone mineral density is reduced in T1DM, whereas patients with T2DM have normal or slightly higher bone density, suggesting impaired bone quality is involved. Detrimental effects of T1DM on the skeleton are more severe than T2DM, probably because of the lack of osteo-anabolic effects of insulin and other pancreatic hormones. In both T1DM and T2DM, low bone quality could be caused by various means, including but not limited to hyperglycemia, accumulation of advanced glycosylation end products (AGEs), decreased serum levels of osteocalcin and parathyroid hormone. Risk for osteoarthritis is also elevated in diabetic population. How diabetes accelerates the deterioration of cartilage remains largely unknown. Hyperglycemia and glucose derived AGEs could contribute to the development of osteoarthritis. Moreover, it is recognized that oral antidiabetic medicines affect bone metabolism and turnover as well. Insulin is shown to have anabolic effects on bone and hyperinsulinemia may help to explain the slightly higher bone density in patients with T2DM. Thiazolidinediones can promote bone loss and osteoporotic fractures by suppressing osteoblastogenesis and enhancing osteoclastogenesis. Metformin favors bone formation by stimulating osteoblast differentiation and protecting them against diabetic conditions such as hyperglycemia. Better knowledge of how diabetic conditions and its treatments influence skeletal tissues is in great need in view of the growing and aging population of patients with diabetes mellitus.
Xue-Lian GAO, Yu-Mei WEI, Hui-Xia YANG, Xian-Ming XU, Ling FAN, Jing HE, Ning LIU, San-Cun ZHAO, Ya-Li HU, Zi YANG, Yun-Ping ZHANG, Xing-Hui LIU, Xu CHEN, Jian-Ping ZHANG, Wen-Li GOU, Mei XIAO, Hai-Rong WU, Mei-Hua ZHANG
《医学前沿（英文）》 2010年 第4卷 第3期 页码 303-307 doi: 10.1007/s11684-010-0090-x
Hui Dong, Fu’er Lu, Nan Wang, Xin Zou, Jingjing Rao
《医学前沿（英文）》 2011年 第5卷 第3期 页码 288-293 doi: 10.1007/s11684-011-0127-9
关键词： diabetes mellitus type 2 haemorheology non-alcoholic fatty liver disease
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《医学前沿（英文）》 2014年 第8卷 第4期 页码 471-476 doi: 10.1007/s11684-014-0365-8
This work aims to estimate the value of diffusion weighted imaging (DWI) and diffusion tensor imaging (DTI) in detecting early-stage kidney injury in type 2 diabetic patients with normoalbuminuria (NAU) versus microalbuminuria (MAU) prospectively. A total of 30 T2DM patients with normal kidney function were recruited and assigned to the NAU group (n = 14) or MAU group (n= 16) according to 8 h overnight urinary albuminuria excretion rate (AER) results. A contemporary cohort of health check-up recipients were included as controls (n = 12). DWI and DTI scans were performed on bilateral kidney using SE single-shot EPI, and apparent diffusion coefficient (ADC) and fractional anisotropy (FA) of the renal parenchyma was determined from ADC and FA maps of the three groups. ADC and FA values were compared among the three groups. According to DWI with a b value of 400 s/mm2, the MAU and NAU groups showed significantly lowered mean ADC values compared with the healthy controls (P<0.01). The mean ADC in the MAU group [(2.22±0.07)×10–3 mm2/s] was slightly lower than that of the NAU group [(2.31±0.22)×10–3 mm2/s], but this difference was not statistically significant (P>0.05). The FA value in the MAU group was higher than that in the control group (0.45±0.07 vs. 0.39±0.03, P = 0.004) but did not differ from that in the NAU group (0.42±0.03) (P>0.05). ADC and FA values may be more sensitive than urine AER in reflecting early-stage kidney injury and, hence, may facilitate earlier detection and quantitative evaluation of kidney injury in T2DM patients. Combined evaluation of ADC and FA values may provide a better quantitative approach for identifying diabetic nephropathy at early disease stages.
关键词： type 2 diabetes mellitus microalbuminuria diffusion weighted imaging diffusion tensor imaging early-stage kidney injury
New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation
《医学前沿（英文）》 2022年 第16卷 第1期 页码 17-24 doi: 10.1007/s11684-021-0873-2
Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma
《医学前沿（英文）》 2018年 第12卷 第6期 页码 688-696 doi: 10.1007/s11684-018-0662-8
Xiao Ke Qing (XKQ) granule has been clinically used to treat type 2 diabetes mellitus (T2DM) for 10 years in Chinese traditional medication. However, its mechanisms against hyperglycemia remain poorly understood. This study aims to investigate XKQ mechanisms on diabetes and diabetic liver disease by using the KKAy mice model. Our results indicate that XKQ can significantly reduce food and water intake. XKQ treatment also remarkably decreases both the fasting blood glucose and blood glucose in the oral glucose tolerance test. Additionally, XKQ can significantly decrease the serum alanine aminotransferase level and liver index and can alleviate the fat degeneration in liver tissues. Moreover, XKQ can ameliorate insulin resistance and upregulate the expression of IRS-1, PI3K (p85), p-Akt, and GLUT4 in the skeletal muscle of KKAy mice. XKQ is an effective drug for T2DM by ameliorating insulin resistance and regulating the PI3K/Akt signaling pathway in the skeletal muscle.
关键词： XKQ type 2 diabetes mellitus KKAy mice PI3K/Akt pathway diabetic liver disease
Hui Wang, Yang Zhang, Zhujun Shen, Ligang Fang, Zhenyu Liu, Shuyang Zhang
《医学前沿（英文）》 2021年 第15卷 第1期 页码 70-78 doi: 10.1007/s11684-020-0749-x
关键词： myocardial infarction percutaneous coronary intervention diabetes mellitus fasting glucose heart failure
血浆代谢组学结合超微弱发光表征早期2型糖尿病的中医证型 Article
何敏, 孙濛濛, Slavik Koval, Roeland Van Wijk, Thomas Hankemeier, Jan Van der Greef, Eduard P.A. Van Wijk, 王梅
《工程（英文）》 2019年 第5卷 第5期 页码 916-923 doi: 10.1016/j.eng.2019.03.011
2型糖尿病（T2DM）的患病率在全球范围内呈迅速上升趋势。因通用干预措施收效甚微，所以疾病研究的重点已经转向个性化策略，特别是疾病的早期阶段的个性化策略。中医基于系统观建立并结合了个性化策略，提高了我们对个性化诊断的认识。从系统生物学的角度，例如将代谢组学与其他系统性诊断方法（如超微弱发光）相结合，可提高对个性化诊断的理解，同时为此类个性化诊疗策略提供生化相关物质基础。在本研究中，我们研究了44名处于2型糖尿病前期的受试者的血浆代谢组学，探讨了基于以下中医亚型进行疾病早期分型的可行性：气阴两虚、气阴两虚挟痰湿、气阴两虚挟血瘀。此外，通过血浆代谢组学和超微弱发光在中医亚分型方面的关系，获得体内生化参数与体外表征参数的关联性信息，从而尝试对疾病亚型分类及判断有更深一步的阐释。结果表明，血浆代谢物的主成分分析揭示了从中医角度划分的2型糖尿病前期不同亚型之间的差异性。对于3种2型糖尿病前期亚型，相对含量较高的脂质（如胆固醇酯和甘油三酯）是鉴别其中之二的重要元素，并且可能与较高的心血管疾病风险相关。血浆代谢组学数据表明，血脂谱是超微弱发光在2型糖尿病亚型分型中收集的重要组成部分。结果表明，2型糖尿病前期的不同中医亚型之间存在代谢差异，可通过血浆代谢物分析来区分这些亚型，血浆代谢组学为系统性超微弱发光体表测量提供了生化参数相关依据。
Early-onset diabetes: an epidemic in China
Jiemin Pan, Weiping Jia
《医学前沿（英文）》 2018年 第12卷 第6期 页码 624-633 doi: 10.1007/s11684-018-0669-1
Although type 2 diabetes is a disease often associated with aging, the global prevalence of early-onset diabetes has been increasing due to man’s sedentary lifestyle, low-physical activity, obesity, and some non-modifiable risk factors. Many studies have found that individuals with early-onset type 2 diabetes were at higher risk of developing vascular complications than those with late-onset diabetes. Individuals with early-onset diabetes are usually unwilling to visit hospital and have more confidence in their health, which results in poor glycemic control and the delayed detection of diabetes-related complications. Few studies have focused on the treatment and prevention of complications in specific population of individuals with early-onset type 2 diabetes. Therefore, focusing on this particular population is critical for the government and academic societies. Screening for T2DM is imminent for young adults with a family history of diabetes, obesity, markers of insulin resistance, or alcohol consumption. More data are definitely required to establish a reasonable risk model to screen for early-onset diabetes.
Metabolomics in human type 2 diabetes research
null
《医学前沿（英文）》 2013年 第7卷 第1期 页码 4-13 doi: 10.1007/s11684-013-0248-4
The high prevalence of diabetes and diabetic complications has caused a huge burden on the modern society. Although scientific advances have led to effective strategies for preventing and treating diabetes over the past several decades, little progress has been made toward curing the disease or even getting it under control, from a public health and overall societal standpoint. There is still a lack of reliable biomarkers indicative of metabolic alterations associated with diabetes and different drug responses, highlighting the need for the development of early diagnostic and prognostic markers for diabetes and diabetic complications. The emergence of metabolomics has allowed researchers to systemically measure the small molecule metabolites, which are sensitive to the changes of both environmental and genetic factors and therefore, could be regarded as the link between genotypes and phenotypes. During the last decade, the progression made in metabolomics has provided insightful information on disease development and disease onset prediction. Recent studies using metabolomics approach coupled with statistical tools to predict incident diabetes revealed a number of metabolites that are significantly altered, including branched-chain and aromatic amino acids, such as isoleucine, leucine, valine, tyrosine and phenylalanine, as diagnostic or highly-significant predictors of future diabetes. This review summarizes the current findings of metabolomic studies in human investigations with the most common form of diabetes, type 2 diabetes.
关键词： metabolomics type 2 diabetes metabolic pathway mass spectrometry nuclear magnetic resonance (NMR)
A case of thymic Langerhans cell histiocytosis with diabetes insipidus as the first presentation
null
《医学前沿（英文）》 2013年 第7卷 第1期 页码 143-146 doi: 10.1007/s11684-013-0238-6
Langerhans cell histiocytosis (LCH) is an idiopathic group of reactive proliferative diseases linked to aberrant immunity, pathologically characterized by clonal proliferation of Langerhans cells. LCH rarely involves the thymus. We report a case of thymic LCH with diabetes insipidus as the first presentation, without evidence of myasthenia gravis and without evidenced involvement of the skin, liver, spleen, bones, lungs and superficial lymph nodes. This present case may have important clinical implications. In screening for LCH lesions, attention should be attached to rarely involved sites in addition to commonly involved organs. Follow-up and imageological examination are very important to a final diagnosis.
关键词： diabetes insipidus thymus Langerhans cell histiocytosis
标题 作者 时间 类型 操作
Correlation between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetesmellitus: a cross-sectional cohort study
Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang
期刊论文
Association of periodontal disease with glycemic control in patients with type 2 diabetes in Indian population
null
期刊论文
Cytokines and inflammation in adipogenesis: an updated review
Ning Jiang, Yao Li, Ting Shu, Jing Wang
期刊论文
Difference between 2 h and 3 h 75 g glucose tolerance test in the diagnosis of gestational diabetes mellitus
Xue-Lian GAO, Yu-Mei WEI, Hui-Xia YANG, Xian-Ming XU, Ling FAN, Jing HE, Ning LIU, San-Cun ZHAO, Ya-Li HU, Zi YANG, Yun-Ping ZHANG, Xing-Hui LIU, Xu CHEN, Jian-Ping ZHANG, Wen-Li GOU, Mei XIAO, Hai-Rong WU, Mei-Hua ZHANG
期刊论文
Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological abnormalities
Hui Dong, Fu’er Lu, Nan Wang, Xin Zou, Jingjing Rao
期刊论文
evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2 diabetics with normoalbuminuria versus microalbuminuria
null
期刊论文
Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway in KKAy mice
Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma
期刊论文
Prognostic value of fasting glucose on the risk of heart failure and left ventricular systolic dysfunction in non-diabetic patients with ST-segment elevation myocardial infarction
Hui Wang, Yang Zhang, Zhujun Shen, Ligang Fang, Zhenyu Liu, Shuyang Zhang
期刊论文
血浆代谢组学结合超微弱发光表征早期2型糖尿病的中医证型
何敏, 孙濛濛, Slavik Koval, Roeland Van Wijk, Thomas Hankemeier, Jan Van der Greef, Eduard P.A. Van Wijk, 王梅
期刊论文
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